This Article Free Full Text (Free PDF) Free References Alert me when this article is cited Alert me if a correction is posted Citation Map Services Email this article to a friend Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Add to Saved Citations Download to citation manager Request Permissions Request Reprints Add to My Marked Citations Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Citing Articles via Scopus Google Scholar Articles by Faler, B. J. Articles by Sidawy, A. N. Search for Related Content PubMed PubMed Citation Articles by Faler, B. J. Articles by Sidawy, A. N. Pubmed/NCBI databases Substance via MeSH Social Bookmarking                         What's this?

Transforming Growth Factor-ß and Wound Healing

Departments of Surgery, Veterans Affairs Medical Center, Walter Reed Army Medical Center; Washington, DC

Robyn A. Macsata, MD

Dahlia Plummer, MD

Departments of Surgery, Veterans Affairs Medical Center; Washington, DC

Lopa Mishra, MD

Departments of Surgery, Veterans Affairs Medical Center, Georgetown University Medical Center; Washington, DC

Anton N. Sidawy, MD

Departments of Surgery, Veterans Affairs Medical Center, Georgetown University Medical Center, George Washington University Medical Center; Washington, DC

Acute and chronic wounds are a source of significant morbidity for patients, and they demand a growing portion of health-care time and finances to be devoted to their care. Transforming growth factor-ß (TGF-ß) has surfaced from abundant research as a key signal in orchestrating wound repair. In beginning this review, we discuss the inflammatory, proliferative, and maturational phases of wound healing. We then focus on TGF-ß by first discussing the pathway from its production to the target cell where Smad proteins execute an intracellular signaling cascade. To review TGF-ß's role in wound healing, we discuss the actions of it individually on keratinocytes, fibroblasts, endothelial cells, and monocytes, which are the major cell types involved in wound repair. From illustrating these cellular actions of TGF-ß, we summarize its multipotent role in the process of wound repair. As a clinical correlation, we also review research dedicated to the involvement of TGF-ß in venous stasis ulcers.

Key Words: transforming growth factor-beta • Smad proteins • wound healing • venous stasis ulcer

Perspectives in Vascular Surgery and Endovascular Therapy, Vol. 18, No. 1, 55-62 (2006)
DOI: 10.1177/153100350601800123


CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    Twitter    What's this?

This article has been cited by other articles:

				S. Bu, B. Kapanadze, T. Hsu, and M. Trojanowska Opposite Effects of Dihydrosphingosine 1-Phosphate and Sphingosine 1-Phosphate on Transforming Growth Factor-{beta}/Smad Signaling Are Mediated through the PTEN/PPM1A-dependent Pathway J. Biol. Chem., July 11, 2008; 283(28): 19593 - 19602. [Abstract] [Full Text] [PDF]

				A. M. Reitzel, J. C. Sullivan, N. Traylor-knowles, and J. R. Finnerty Genomic Survey of Candidate Stress-Response Genes in the Estuarine Anemone Nematostella vectensis Biol. Bull., June 1, 2008; 214(3): 233 - 254. [Abstract] [Full Text] [PDF]

				A. Semlali, E. Jacques, S. Plante, S. Biardel, J. Milot, M. Laviolette, L.-P. Boulet, and J. Chakir TGF- Suppresses EGF-Induced MAPK Signaling and Proliferation in Asthmatic Epithelial Cells Am. J. Respir. Cell Mol. Biol., February 1, 2008; 38(2): 202 - 208. [Abstract] [Full Text] [PDF]

				S. K. Sze, D. P. V. de Kleijn, R. C. Lai, E. Khia Way Tan, H. Zhao, K. S. Yeo, T. Y. Low, Q. Lian, C. N. Lee, W. Mitchell, et al. Elucidating the Secretion Proteome of Human Embryonic Stem Cell-derived Mesenchymal Stem Cells Mol. Cell. Proteomics, October 1, 2007; 6(10): 1680 - 1689. [Abstract] [Full Text] [PDF]