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Perspectives in Vascular Surgery and Endovascular Therapy
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Transforming Growth Factor-ß and Wound Healing

Byron J. Faler, MD

Departments of Surgery, Veterans Affairs Medical Center, Walter Reed Army Medical Center; Washington, DC

Robyn A. Macsata, MD

Dahlia Plummer, MD

Departments of Surgery, Veterans Affairs Medical Center; Washington, DC

Lopa Mishra, MD

Departments of Surgery, Veterans Affairs Medical Center, Georgetown University Medical Center; Washington, DC

Anton N. Sidawy, MD

Departments of Surgery, Veterans Affairs Medical Center, Georgetown University Medical Center, George Washington University Medical Center; Washington, DC

Acute and chronic wounds are a source of significant morbidity for patients, and they demand a growing portion of health-care time and finances to be devoted to their care. Transforming growth factor-ß (TGF-ß) has surfaced from abundant research as a key signal in orchestrating wound repair. In beginning this review, we discuss the inflammatory, proliferative, and maturational phases of wound healing. We then focus on TGF-ß by first discussing the pathway from its production to the target cell where Smad proteins execute an intracellular signaling cascade. To review TGF-ß's role in wound healing, we discuss the actions of it individually on keratinocytes, fibroblasts, endothelial cells, and monocytes, which are the major cell types involved in wound repair. From illustrating these cellular actions of TGF-ß, we summarize its multipotent role in the process of wound repair. As a clinical correlation, we also review research dedicated to the involvement of TGF-ß in venous stasis ulcers.

Key Words: transforming growth factor-beta • Smad proteins • wound healing • venous stasis ulcer

References

Perspectives in Vascular Surgery and Endovascular Therapy, Vol. 18, No. 1, 55-62 (2006)
DOI: 10.1177/153100350601800123
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This Article
Right arrow Abstract Freely available
Right arrow Free Full Text (Free PDF) Free
Right arrow Alert me when this article is cited
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Citing Articles
Right arrow Citing Articles via HighWire
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Google Scholar
Right arrow Articles by Faler, B. J.
Right arrow Articles by Sidawy, A. N.
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PubMed
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