Perspectives in Vascular Surgery and Endovascular Therapy

 

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This version was published on March 1, 2008
Perspectives in Vascular Surgery and Endovascular Therapy, Vol. 20, No. 1, 45-47 (2008)
DOI: 10.1177/1531003507313300

The Use of Stem Cells in the Treatment of Inoperable Limb Ischemia

William H. Pearce, MD

Division of Vascular Surgery, Diseases Northwestern University, wpearce{at}nmh.org

Richard Burt, MD

Division of Immunotherapy for Autoimmune Diseases Northwestern University, Feinberg School of Medicine, Chicago, Illinois

Heron E. Rodriguez, MD

Division of Vascular Surgery, Diseases Northwestern University

Autologous stem cell-based therapy offers many advantages over other nonsurgical treatments of peripheral arterial disease. Transplant stem cells are a renewable source of multiple cytokines and growth factors. Autologous adult stem cells are not rejected and do not form teratomas. Early preliminary results indicate that adult stem cell therapy is safe and effective in patients with critical limb ischemia.

Key Words: peripheral arterial disease • critical limb ischemia • stem cell therapy • revascularization


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