Perspectives in Vascular Surgery and Endovascular Therapy

 

Advanced Search

Journal Navigation

Journal Home

Subscriptions

Archive

Contact Us

Table of Contents

Register here to gain access to SAGE's 500+ Journals Online

Click here to browse AJSM online!

Sign In to gain access to subscriptions and/or personal tools.
This Article
Right arrow Full Text (PDF)
Right arrow References
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Alert me to new issues of the journal
Right arrow Add to Saved Citations
Right arrow Download to citation manager
Right arrowRequest Permissions
Right arrow Request Reprints
Right arrow Add to My Marked Citations
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Myers, S. I.
Right arrow Search for Related Content
PubMed
Right arrow Articles by Myers, S. I.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us   Add to Digg   Add to Reddit   Add to Technorati  
What's this?
Perspectives in Vascular Surgery and Endovascular Therapy, Vol. 17, No. 3, 269-1-271 (2005)
DOI: 10.1177/153100350501700320

COX-2-Derived Prostacyclin Confers Atheroprotection on Female Mice

Stuart I. Myers, MD, FACS

McGuire Research Institute and The Department of Surgery, Virginia Commonwealth University, Ninth Floor, West Hospital, 1200 E. Broad St., Richmond, VA 23298-0108 simyers{at}vcu.edu

The authors report a study of the action of estrogen on estrogen receptor subtype cx to up-regulate the production of atheroprotective prostycyclin (PG61) by activation of cyclooxygenase-2 (COX-2). Oxidant stress and platelet activation that contribute to atherogenesis in female mice was restrained. The data suggest that the long-term use of selective COX-2 inhibitors could undermine protection from cardiovascular disease in women who are premenopausal.

Key Words: PGI • atherosclerosis • low-density-l poprotein receptor • cyclooxygenase-2


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us   Add to Digg Digg   Add to Reddit Reddit   Add to Technorati Technorati    What's this?