| Sign In to gain access to subscriptions and/or personal tools. |
DOI: 10.1177/153100350501700320 COX-2-Derived Prostacyclin Confers Atheroprotection on Female MiceMcGuire Research Institute and The Department of Surgery, Virginia Commonwealth University, Ninth Floor, West Hospital, 1200 E. Broad St., Richmond, VA 23298-0108 simyers{at}vcu.edu The authors report a study of the action of estrogen on estrogen receptor subtype cx to up-regulate the production of atheroprotective prostycyclin (PG61) by activation of cyclooxygenase-2 (COX-2). Oxidant stress and platelet activation that contribute to atherogenesis in female mice was restrained. The data suggest that the long-term use of selective COX-2 inhibitors could undermine protection from cardiovascular disease in women who are premenopausal.
Key Words: PGI atherosclerosis low-density-l poprotein receptor cyclooxygenase-2
|