Perspectives in Vascular Surgery and Endovascular Therapy

 

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Perspectives in Vascular Surgery and Endovascular Therapy, Vol. 17, No. 1, 60-1-62 (2005)
DOI: 10.1177/153100350501700111

Circulating Monocytes and In-Stent Neointima After Coronary Stent Implantation

Alexander W. Clowes, MD

Division of Vascular Surgery, Department of Surgery, University of Washington School of Medicine, Box 356410, Seattle, WA 98195-6410.

The authors investigated the relationship between circulating white blood cells, especially monocytes, and restenosis after stent implantation. Coronary stents were placed in 107 patients. The white blood cell fraction count was analyzed from peripheral blood obtained from patients immediately before the procedures and repeated after the procedure for 7 days. Patients received angiographic and volumetric intravascular ultrasound analysis at 6-month follow-up. The counts of circulating monocytes increased and peaked 2 days after stent implantation. A multiregression analysis showed a significant positive correlation with in-stent neointimal volume with stent volume immediately after implantation and maximum monocyte count. Twenty-two patients with angiographic restenosis showed a significantly larger maximum monocyte count than the patients without restenosis. The authors concluded that circulating monocytes contribute to the process of in-stent neointimal hyperplasia.

Key Words: restenosis • intimal hyperplasia • smooth musce cell • monocyte • macrophage • stent angioplasty


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