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Effect of Simvastatin Versus Placebo on Treadmill Exercise Time Until the Onset of Intermittent Claudication in Older Patients With Peripheral Arterial Disease at Six Months and at One Year After Treatment

University of Arkansas for Medical Sciences, 4301 W Markham St, Box 520-2, Little Rock, AR 72227; EidtjohnF{at}UAMS.EDU

The authors conducted a study to investigate the effect of simvastatin after 6 months and 1 year on the time to onset of intermittent claudication during treadmill exercise in patients with peripheral arterial disease. Thirty-four patients were randomized to simvastatin, 35 were randomized to placebo. Simvastatin therapy resulted in a 24% increased treadmill exercise time until onset of intermittent claudication from baseline at 6 months and by 42% at 1 year.

Key Words: simvastatin • treadmill exercise • peripheral arterial disease

Perspectives in Vascular Surgery and Endovascular Therapy, Vol. 16, No. 4, 334-336 (2004)
DOI: 10.1177/153100350401600421


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