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Perspectives in Vascular Surgery and Endovascular Therapy, Vol. 16, No. 2, 153-154 (2004)
DOI: 10.1177/153100350401600222
© 2004 SAGE Publications

Use of Abciximab During Infrainguinal Peripheral Vascular Interventions: Initial Experience

Michael B. Silva, Jr., MD

Divisions of Vascular Surgery and Vascular Intervention-al Radiology, Texas Tech University Health Sciences Center, Lubbock, Texas; mbs2{at}aol.com

W. Todd Bohannon, MD

Divisions of Vascular Surgery and Vascular Intervention-al Radiology, Texas Tech University Health Sciences Center, Lubbock, Texas

The use of abciximab in conjunction with infrainguinal angioplasty in 16 patients over an 18-month period in 1999 was investigated. Abciximab was given to patients thought to be at high risk for a thrombotic or embolic complication. Ten patients had high-grade stenoses or occlusions in the popliteal artery and superficial femoral artery; six patients had stenoses or occlusions below the popliteal artery. After arterial access was achieved, all patients received a bolus of heparin. A weight-based nomogram, consisting of an initial bolus followed by an overnight infusion, was used to administer the abciximab. A less than 30% residual stenosis after angioplasty was considered a technical success. Patients were monitored for complications following the procedure and platelet counts were monitored for 24 hours. Technical success occurred in 94% (15116) of the patients. No significant effect on platelet count was noted. Two minor complications occurred. The major complication was a groin hematoma in a patient who was also undergoing chronic antiplatelet therapy with aspirin and clopidogrel. Abciximab has promise as an adjunct during complex infrainguinal arterial interventions but further study is needed.

Key Words: infrainguinal angioplasty • stenosis • popliteal artery • superficial femoral artery


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