Perspectives in Vascular Surgery and Endovascular Therapy

 

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Perspectives in Vascular Surgery and Endovascular Therapy, Vol. 16, No. 2, 141-142 (2004)
DOI: 10.1177/153100350401600215

Role of Hyperbaric Oxygen Therapy in lschemic Diabetic Lower Extremity Ulcers: A Double-Blind Randomisedcontrolled Trial

William A. Marston, MD

Division of Vascular Surgery, University of North Carolina School of Medicine, Campus Box 7212, 130 Mason Farm Road, 2146 Bioinformatics Building, University of North Carolina, Chapel Hill, NC 27599- 7212; sky{at}med.unc.edu

The authors conducted a study to evaluate the role of hyperbaric oxygen in the treatment of ischemic lower-extremity ulcers in patients with peripheral arterial disease. In patients with diabetes mellitus, these ulcers are associated with high risk of limb-threatening complications. Diabetic patients were randomized to hyperbaric oxygen treatment (100%) (n = 9) or control (air) (n = 9) at 2.4 atmospheres of absolute pressure for 90 minutes daily (30 treatments). There were no adverse events related to the hyperbaric therapy. In the treatment group, complete healing was achieved in five of the eight ulcers at 6 weeks, compared with one out of eight in the control group. The authors concluded that hyperbaric oxygen enhanced the healing of ischemic, non-healing diabetic leg ulcers.

Key Words: hyperbaric oxygen • diabetes mellitus • ischemic ulcers • peripheral arterial disease


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